From Chattanooga, TN take I-75 North to exit 20 (64 By-Pass Exit to Cleveland, TN) which is also HWY 74.  Take this to the 64 East exit toward Ocoee, TN.  You will go thru Murphy and Andrews, NC.

Follow Highway 19/74 East. Once the four lane highway turns into a two lane highway go about 20 miles to Nantahala Cabins which is on the right.